Rhodium-Catalyzed Highly Enantioselective Hydrogenation of a Tetrasubstituted Enamine
نویسندگان
چکیده
منابع مشابه
Enantioselective synthesis of beta2-amino acids using rhodium-catalyzed hydrogenation.
A series of protected beta2-dehydroamino acids has been prepared in three steps from commercially available starting materials in good yields. These were used as substrates in rhodium-catalyzed asymmetric hydrogenation applying a mixed ligand system of monodentate phosphoramidites and phosphines. Optimization of the catalyst structure was achieved by high throughput experimentation. High enanti...
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We achieved highly enantioselective synthesis of cyclic 1,2-sulfamidates and -sulfamides via rhodium-catalyzed transfer hydrogenation, and also revealed one-pot preparation of cyclic N-sulfonylimines from α-hydroxy ketones.
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Chiral phosphine-phosphites provide versatile catalysts for the highly enantioselective hydrogenation of alpha-acyloxy alpha, beta-unsaturated phosphonates.
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Although significant progress has been made in the catalytic asymmetric reduction of ketones and olefins over the last few decades, the asymmetric reduction of imines remains a major challenge. Enantioselective reductive amination with organocatalysts has recently been reported, and a number of transition-metal-based catalysts, such as those containing Rh, Ru, Ti, Zr, and Ir, have been applied ...
متن کاملHighly Enantioselective Hydrogenation of a-Keto Esters Catalyzed by Ru-Tunephos Complexes Highly Enantioselective Hydrogenation of a-Keto Esters
SYNLETT 2006, No. 8, pp 1169–117215.05.2006 Advanced online publication: 10.03.2006 DOI: 10.1055/s-2006-932461; Art ID: W30605ST © Georg Thieme Verlag Stuttgart · New York Abstract: Various enantiomerically pure a-hydroxy esters were synthesized by asymmetric hydrogenation of a-keto esters catalyzed by Ru-Cn-Tunephos complex. Up to 97.1% ee has been achieved for both a-aryl and a-alkyl substitu...
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ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2021
ISSN: 1083-6160,1520-586X
DOI: 10.1021/acs.oprd.1c00007